Review Article

Systemic Lupus Erythematosus and Depression Overview

Ahmed Shaaban*, Nourelhouda Said and Hoda Afifi

Published: 03 January, 2024 | Volume 8 - Issue 1 | Pages: 001-004

Systemic lupus erythematosus (SLE) is a chronic inflammatory multisystem disorder that commonly affects females during their reproductive years. It is characterized by the presence of autoantibodies and immune complex deposition, the etiology is not known but the interaction of an environmental agent in a genetically susceptible individual is thought to be fundamental. SLE most frequently involves the skin, joints, lungs, heart, kidney, and neuropsychiatric manifestations that may occur during the course of the disease. Mood disorders among SLE patients, particularly depression, are common and important psychiatric manifestations of the disease, in addition to their high incidence and possible deleterious influence on disease progression, so early identification and treatment of depression may have a significant influence on the patient’s quality of life.

Read Full Article HTML DOI: 10.29328/journal.ida.1001039 Cite this Article Read Full Article PDF


  1. D’Cruz DP, Khamashta MA, Hughes GR. Systemic lupus erythematosus. Lancet. 2007; 369(9561):587–596.
  2. Crow MK, Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR. Etiology and pathogenesis of systemic lupus erythematosus. Kelley's Textbook of Rheumatology. 9th Philadelphia, PA: Elsevier Saunders. 2013; 1269-82
  3. Jeltsch-David H, Muller S. Neuropsychiatric systemic lupus erythematosus: pathogenesis and biomarkers. Nat Rev Neurol. 2014 Oct;10(10):579-96. doi: 10.1038/nrneurol.2014.148. Epub 2014 Sep 9. PMID: 25201240.
  4. Palagini L, Mosca M, Tani C, Gemignani A, Mauri M, Bombardieri S. Depression and systemic lupus erythematosus: a systematic review. Lupus. 2013 Apr;22(5):409-16. doi: 10.1177/0961203313477227. Epub 2013 Feb 20. PMID: 23427220.
  5. Katon WJ. Clinical and health services relationships between major depression, depressive symptoms, and general medical illness. Biol Psychiatry. 2003 Aug 1;54(3):216-26. doi: 10.1016/s0006-3223(03)00273-7. PMID: 12893098.
  6. Julian LJ, Gregorich SE, Tonner C, Yazdany J, Trupin L, Criswell LA, Yelin E, Katz PP. Using the Center for Epidemiologic Studies Depression Scale to screen for depression in systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2011 Jun;63(6):884-90. doi: 10.1002/acr.20447. PMID: 21312347; PMCID: PMC3719846.
  7. Shaaba A, Tayel M, Hassan E , Salah M, Ibrahim M, Said W. Evaulation of deoression and general health assement among systemic lupus erythematosus patients in relation to disease activity and damage. Egyptian Rheumatology and Rehabilitaion. 2022; 45:19. https://doi.org/10.1186/s43166-022-00113-5
  8. Stoll T, Kauer Y, Büchi S, Klaghofer R, Sensky T, Villiger PM. Prediction of depression in systemic lupus erythematosus patients using SF-36 Mental Health scores. Rheumatology (Oxford). 2001 Jun;40(6):695-8. doi: 10.1093/rheumatology/40.6.695. PMID: 11426030.
  9. Ravindran AV, Matheson K, Griffiths J, Merali Z, Anisman H. Stress, coping, uplifts, and quality of life in subtypes of depression: a conceptual frame and emerging data. J Affect Disord. 2002 Sep;71(1-3):121-30. doi: 10.1016/s0165-0327(01)00389-5. PMID: 12167508.
  10. Zandman-Goddard G, Chapman J, Shoenfeld Y. Autoantibodies involved in neuropsychiatric SLE and antiphospholipid syndrome. Semin Arthritis Rheum. 2007 Apr;36(5):297-315. doi: 10.1016/j.semarthrit.2006.11.003. Epub 2007 Jan 26. PMID: 17258299.
  11. Braga J, Campar A. Causas biológicas de depressão em doentes com Lupus Eritematoso Sistémico: um estudo de revisão [Biological causes of depression in Systemic Lupus Erythematosus]. Acta Reumatol Port. 2014 Jul-Sep;39(3):218-26. Portuguese. PMID: 25326402.
  12. Giovacchini G, Mosca M, Manca G, Della Porta M, Neri C, Bombardieri S, Ciarmiello A, Strauss HW, Mariani G, Volterrani D. Cerebral blood flow in depressed patients with systemic lupus erythematosus. J Rheumatol. 2010 Sep;37(9):1844-51. doi: 10.3899/jrheum.100121. Epub 2010 Jul 1. PMID: 20595265.
  13. Xie LF, Chen PL, Pan HF, Tao JH, Li XP, Zhang YJ, Zhai Y, Ye DQ. Prevalence and correlates of suicidal ideation in SLE inpatients: Chinese experience. Rheumatol Int. 2012 Sep;32(9):2707-14. doi: 10.1007/s00296-011-2043-3. Epub 2011 Jul 27. PMID: 21792644.
  14. Nery FG, Borba EF, Hatch JP, Soares JC, Bonfá E, Neto FL. Major depressive disorder and disease activity in systemic lupus erythematosus. Compr Psychiatry. 2007 Jan-Feb;48(1):14-9. doi: 10.1016/j.comppsych.2006.04.002. Epub 2006 May 24. PMID: 17145276.
  15. Stringhini S, Sabia S, Shipley M, Brunner E, Nabi H, Kivimaki M, Singh-Manoux A. Association of socioeconomic position with health behaviors and mortality. JAMA. 2010 Mar 24;303(12):1159-66. doi: 10.1001/jama.2010.297. PMID: 20332401; PMCID: PMC2918905.
  16. Dietz B, Katz P, Dall'Era M, Murphy LB, Lanata C, Trupin L, Criswell LA, Yazdany J. Major Depression and Adverse Patient-Reported Outcomes in Systemic Lupus Erythematosus: Results From a Prospective Longitudinal Cohort. Arthritis Care Res (Hoboken). 2021 Jan;73(1):48-54. doi: 10.1002/acr.24398. Epub 2020 Dec 6. PMID: 32741124; PMCID: PMC7775294.
  17. Zakeri Z, Shakiba M, Narouie B, Mladkova N, Ghasemi-Rad M, Khosravi A. Prevalence of depression and depressive symptoms in patients with systemic lupus erythematosus: Iranian experience. Rheumatol Int. 2012 May;32(5):1179-87. doi: 10.1007/s00296-010-1791-9. Epub 2011 Jan 21. PMID: 21253731.
  18. Nicassio PM. The significance of behavioral interventions for arthritis. In: Weisman MH, Weinblatt ME, Louie JS, Van Vollenhoven RF (eds). Targeted treatment of the rheumatic diseases. 1st 2009; 397–407.
  19. Davidson SK, Romaniuk H, Chondros P, Dowrick C, Pirkis J, Herrman H, Fletcher S, Gunn J. Antidepressant treatment for primary care patients with depressive symptoms: Data from the diamondlongitudinal cohort study. Aust N Z J Psychiatry. 2020 Apr;54(4):367-381. doi: 10.1177/0004867419898761. Epub 2020 Jan 20. PMID: 31957463.
  20. Navarrete-Navarrete N, Peralta-Ramírez MI, Sabio-Sánchez JM, Coín MA, Robles-Ortega H, Hidalgo-Tenorio C, Ortego-Centeno N, Callejas-Rubio JL, Jiménez-Alonso J. Efficacy of cognitive behavioural therapy for the treatment of chronic stress in patients with lupus erythematosus: a randomized controlled trial. Psychother Psychosom. 2010;79(2):107-15. doi: 10.1159/000276370. Epub 2010 Jan 20. PMID: 20090397.
  21. Karlson EW, Liang MH, Eaton H, Huang J, Fitzgerald L, Rogers MP, Daltroy LH. A randomized clinical trial of a psychoeducational intervention to improve outcomes in systemic lupus erythematosus. Arthritis Rheum. 2004 Jun;50(6):1832-41. doi: 10.1002/art.20279. PMID: 15188360.


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